The Grim Adventures of Billy and Mandy
Season 6 Episode 21 - Spidermandy
When Billy finds his "son" Jeff the Spider lying in his bed with "Spider Pox", he goes to Mandy for help to get rid of the giant spider. While ignoring Billy, the next morning Mandy awakens afflicted by Spider Pox too, developing four additional arms and the ability to produce spider web. Mandy's condition progresses and she completely turns into a giant spider, who captures Billy's parents and Grim. Grim tells Billy that, to cure Mandy, he must use the venom of the spider that infected her. While Billy successfully gives Mandy Jeff's venom, he also carried the virus and infected the people of the city, who have all turned into spiders.
Episodes in Season 6
Billy Ocean
Hill Billy
Keeper of the Reaper
15 min
The Love That Dare Not Speak Its Name
Major Cheese
Modern Primitives
Giant Billy and Mandy All Out Attack
The Wrongest Yard
Druid, Where's My Car?
Herbicidal Maniac
Chaos Theory
A Grim Day
Pandora's Lunch Box
Billy and Mandy vs. the Martians
15 min
Dumb-Dumbs and Dragons
Fear and Loathing in Endsville
Dad Day Afternoon
Scary Poppins
Hurter Monkey
Goodbling and the Hip-Hop-Opotamus
Spidermandy
Be A-Fred, Be Very A-Fred
30 min